The old school of thought believes that eczema is caused by allergy leading to abnormal functioning of immune system.
These views have been constantly challenged by evidence of current research which links this inflammatory disease to compromised skin barrier due to genetic mutation. Skins of these patients are also proven to be lack of adequate antimicrobial peptides which is our first line of depend against microorganisms and lack of natural moisturizers. The lack of optimal ability of the skin to repair and to fight microorganism have led to hyperactive and dysfunctional immune system. Abnormal immune system functioning is the clinical manifestation of eczema but not the cause! These deregulated immune system activity is a desperate attempt of the skin to repair and to rid of invasive microorganisms. Treatments which aim to restore or enhance skin barrier and to kill microbes have been proven to improve eczema.